Music is a fundamentally human activity that is celebrated worldwide and from a young age, but why we know and love our music has remained a mystery. Epic successes and failures in the human history of music, from Mozart to Hillary Clinton, are informative of the neural systems that give rise to musical ability. I will describe behavioral, structural and functional neuroimaging, and brain-stimulation studies that use music as a model to understand and to capitalize on the interaction of perception, action, cognition, and emotion in the human nervous system. Results suggest that much of what we know and love about music is learned from statistics of sounds in the environment, and that structural and functional connectivity between perceptual and motor systems subserve the musical experiences that may overlap in different extents with language, creativity, abstract reasoning, and affective communication.